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SARS-CoV-2 shares roughly 79% and 50% genetic similarity with SARS-CoV-1 and MERS-CoV, respectively (Lu et al., 2020), but is strikingly 96.1% genetically similar to bat CoV-RaTG13 (H. Zhou, Chen, et al., 2020). This relatively high genetic similarity with SARS-CoV-1 suggests that SARS-CoV-2 may exert its pathogenesis via similar mechanisms.

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JAKi vs. BAT; planned milestones: open trial 1Q 2021, completion of enrollment 2H 2022, interim analysis 1H 2023, final top-line results 1H 2024 Two Phase 3 Trials with Registration Intent LR MDS: Meaningful and durable transfusion independence recently published in JCO; 29% of patients were transfusion free for ≥1 year**

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For example, animals may perceive the novelty of the laboratory setting, combined with absent or artificial refuges and visits by caretakers and researchers as an environment of elevated and persistent danger. In such situations, animals may lack the means to reduce the threat with adaptive behavioural responses (e.g. hiding, flocking or fleeing).

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Lipolysis drives expression of the constitutively active ...

Accordingly, consecutive truncations of the GPR3 N terminus revealed that the region containing amino acids 18–27 was the most crucial for intrinsic signaling activity (Figures 1F and 1G).Interestingly, treating cells with a peptide fragment comprised only of amino acids 18–27 dose-dependently activated GPR3 (Figure 1H), but not the closely related cannabinoid 1 …

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Abstract. Accurate assessment of anthropogenic carbon dioxide (CO 2 ) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere in a changing climate – the "global carbon budget" – is important to better understand the global carbon cycle, support the development of climate policies, and project future climate change.

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Public Trust in COVID-19 Prevention and Responses Between January and May 2020 in Bangladesh. Alam E, Al Abdouli K, Khamis AH, Bhuiyan HU, Rahman KA. Risk Management and Healthcare Policy 2021, 14:4425-4437 . Published Date: 1 November 2021

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In some cases, the ball may also be a specific ocular hazard. Such sports include the ball sports (soccer, Gaelic football, rugby league, rugby union, basketball, American football), boxing and wrestling. These sports may necessitate protection of the eye, eye and face or the whole head but eye protection alone is relatively rarely seen.

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Journal.pbio.2000638 1. RESEARCH ARTICLE Approach-Induced Biases in Human Information Sampling Laurence T. Hunt1,2 *, Robb B. Rutledge1,3, W. M. Nishantha Malalasekera2, Steven W. Kennerley2, Raymond J. Dolan1,3 1 Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom, 2 Sobell Department of Motor Neuroscience, …

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Abstract In most modern societies, the relationship that many individuals have with food has fundamentally changed from previous generations. People have shifted away from viewing food as primarily sustenance, and rather now seek out foods based on pure palatability or specific nutrition. However, it is far from clear what optimal nutrition is for the general …

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Subunit-Dependent High-Affinity Zinc Inhibition of Acid ...

Acid-sensing ion channels (ASICs), a novel class of ligand-gated cation channels activated by protons, are highly expressed in peripheral sensory and central neurons. Activation of ASICs may play an important role in physiological processes such as nociception, mechanosensation, and learning-memory, and in the pathology of neurological conditions …

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An increasing number of phylogeographic studies on marine species shows discordant patterns in the degree of population differentiation between nuclear and mitochondrial markers. To understand ...

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The efficiency of crop production is defined in thermodynamic terms as the ratio of energy output (carbohydrate) to energy input (solar radiation). Temperature and water supply are the main climatic constraints on efficiency. Over most of Britain, the ...

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